diff --git a/src/System.Management.Automation/engine/remoting/commands/EnterPSHostProcessCommand.cs b/src/System.Management.Automation/engine/remoting/commands/EnterPSHostProcessCommand.cs
index 38169d67b9..51e5e2e9b3 100644
--- a/src/System.Management.Automation/engine/remoting/commands/EnterPSHostProcessCommand.cs
+++ b/src/System.Management.Automation/engine/remoting/commands/EnterPSHostProcessCommand.cs
@@ -13,6 +13,7 @@ using System.Management.Automation.Host;
 using System.Management.Automation.Internal;
 using System.Management.Automation.Remoting;
 using System.Management.Automation.Runspaces;
+using System.Management.Automation.Security;
 using System.Text;
 
 namespace Microsoft.PowerShell.Commands
@@ -126,6 +127,19 @@ namespace Microsoft.PowerShell.Commands
         /// </summary>
         protected override void EndProcessing()
         {
+            // Check if system is in locked down mode, in which case this cmdlet is disabled.
+            if (SystemPolicy.GetSystemLockdownPolicy() == SystemEnforcementMode.Enforce)
+            {
+                WriteError(
+                    new ErrorRecord(
+                        new PSSecurityException(RemotingErrorIdStrings.EnterPSHostProcessCmdletDisabled),
+                        "EnterPSHostProcessCmdletDisabled",
+                        ErrorCategory.SecurityError,
+                        null));
+
+                return;
+            }
+
             // Check for host that supports interactive remote sessions.
             _interactiveHost = this.Host as IHostSupportsInteractiveSession;
             if (_interactiveHost == null)
diff --git a/src/System.Management.Automation/resources/RemotingErrorIdStrings.resx b/src/System.Management.Automation/resources/RemotingErrorIdStrings.resx
index da1b1c6154..42be53c219 100644
--- a/src/System.Management.Automation/resources/RemotingErrorIdStrings.resx
+++ b/src/System.Management.Automation/resources/RemotingErrorIdStrings.resx
@@ -1693,4 +1693,7 @@ All WinRM sessions connected to PowerShell session configurations, such as Micro
   <data name="PSCoreRemotingEnableWarning" xml:space="preserve">
     <value>PowerShell remoting has been enabled only for PowerShell Core configurations and does not affect Windows PowerShell remoting configurations. Run this cmdlet in Windows PowerShell to affect all PowerShell remoting configurations.</value>
   </data>
+  <data name="EnterPSHostProcessCmdletDisabled" xml:space="preserve">
+    <value>Enter-PSHostProcess cmdlet is disabled because an application control policy such as 'AppLocker' or 'Windows Defender Application Control' is in enforcement.</value>
+  </data>
 </root>
diff --git a/test/powershell/Modules/Microsoft.PowerShell.Security/ConstrainedLanguageRestriction.Tests.ps1 b/test/powershell/Modules/Microsoft.PowerShell.Security/ConstrainedLanguageRestriction.Tests.ps1
index e5fe6d081c..19722d62ff 100644
--- a/test/powershell/Modules/Microsoft.PowerShell.Security/ConstrainedLanguageRestriction.Tests.ps1
+++ b/test/powershell/Modules/Microsoft.PowerShell.Security/ConstrainedLanguageRestriction.Tests.ps1
@@ -1164,6 +1164,31 @@ try
         }
     }
 
+    Describe "Enter-PSHostProcess cmdlet should be disabled on locked down systems" -Tags 'Feature','RequireAdminOnWindows' {
+
+        It "Verifies that Enter-PSHostProcess is disabled with lock down policy" {
+
+            $expectedError = $null
+            try
+            {
+                Invoke-LanguageModeTestingSupportCmdlet -SetLockdownMode
+                $ExecutionContext.SessionState.LanguageMode = "ConstrainedLanguage"
+
+                Enter-PSHostProcess -Id 5555 -ErrorAction Stop
+            }
+            catch
+            {
+                $expectedError = $_
+            }
+            finally
+            {
+                Invoke-LanguageModeTestingSupportCmdlet -RevertLockdownMode -EnableFullLanguageMode
+            }
+
+            $expectedError.FullyQualifiedErrorId | Should -BeExactly 'EnterPSHostProcessCmdletDisabled,Microsoft.PowerShell.Commands.EnterPSHostProcessCommand'
+        }
+    }
+
     # End Describe blocks
 }
 finally